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pubblicata il 02.10.2012

Huang, Jinhai, et al. "A comparison between Scheimpflug imaging and optical coherence tomography in measuring corneal thickness." Ophthalmology 120.10 (2013): 1951-1958.


Author information: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Vision Science, Ministry of Health P. R. China, Wenzhou, Zhejiang, China.

PURPOSE:

To assess the repeatability and reproducibility of 3 rotating Scheimpflug cameras, the Pentacam (Oculus, Wetzlar, Germany), Sirius (Costruzione Strumenti Oftalmici, Florence, Italy), and Galilei (Ziemer, Biel, Switzerland), and 1 Fourier-domain optical coherence tomography (FD-OCT) system, the RTvue-100 OCT (Optovue Inc., Fremont, CA), in measuring corneal thickness.

DESIGN:

Evaluation of diagnostic test.

PARTICIPANTS:

Sixty-six right eyes of 66 healthy volunteers, whose mean age ± standard deviation (SD) was 35.39±10.06 years (range, 18-55 years).

METHODS:

Corneal thickness measurements obtained by each system included central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT), measured at superior, inferior, nasal, and temporal locations at a distance of 1 and 2.5 mm from the corneal apex. In the first session, 3 consecutive measurements were performed by the same operator to assess intraobserver repeatability and by a second operator to assess interobserver reproducibility. Measurements were repeated in the second session scheduled 1 day to 1 week later. The mean values obtained in the 2 sessions by the first operator were used to investigate the intersession reproducibility.

MAIN OUTCOME MEASURES:

Intraobserver repeatability and interobserver and intersession repeatability of corneal thickness measurements, as calculated by means of within-subject SD, test-retest repeatability, coefficient of variation (COV), and intraclass correlation coefficients.

RESULTS:

The precision of CCT, TCT, CT2 mm (midperipheral corneal thickness [MPCT] with a distance of 1 mm from the corneal apex), and CT5 mm (midperipheral corneal thickness [MPCT] with a distance of 2.5 mm from the corneal apex) measurements was high with all 4 systems. The COV was ≤1.16%, 0.94%, and 1.10% for repeatability, interobserver reproducibility, and intersession reproducibility, respectively. The 4 devices offered better interobserver reproducibility than intersession reproducibility for all measurements. The CTsuperior-5 mm (midperipheral corneal thickness [MPCT], measured at superior locations with a distance of 2.5 mm from the corneal apex) measurements showed the poorest repeatability and reproducibility. The Galilei revealed the best precision of CCT, TCT, and CT2 mm measurements.

CONCLUSIONS:

Both Scheimpflug imaging and FD-OCT offer highly repeatable and reproducible measurements of CCT and MPCT. The precision was lower in the midperipheral superior quadrant.

FINANCIAL DISCLOSURE(S):

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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